The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors

We have recently reported that lowering the pH to values that are frequently detected in tumors causes reversible anergy in both human and mouse CD8(+) T lymphocytes in vitro. The same occurs in vivo, in the tumor microenvironment and the administration of proton pump inhibitors, which buffer tumor...

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Autores principales: Bellone, Matteo, Calcinotto, Arianna, Filipazzi, Paola, De Milito, Angelo, Fais, Stefano, Rivoltini, Licia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583905/
https://www.ncbi.nlm.nih.gov/pubmed/23483769
http://dx.doi.org/10.4161/onci.22058
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author Bellone, Matteo
Calcinotto, Arianna
Filipazzi, Paola
De Milito, Angelo
Fais, Stefano
Rivoltini, Licia
author_facet Bellone, Matteo
Calcinotto, Arianna
Filipazzi, Paola
De Milito, Angelo
Fais, Stefano
Rivoltini, Licia
author_sort Bellone, Matteo
collection PubMed
description We have recently reported that lowering the pH to values that are frequently detected in tumors causes reversible anergy in both human and mouse CD8(+) T lymphocytes in vitro. The same occurs in vivo, in the tumor microenvironment and the administration of proton pump inhibitors, which buffer tumor acidity, can revert T-cell anergy and increase the efficacy of immunotherapy.
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spelling pubmed-35839052013-03-11 The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors Bellone, Matteo Calcinotto, Arianna Filipazzi, Paola De Milito, Angelo Fais, Stefano Rivoltini, Licia Oncoimmunology Author's View We have recently reported that lowering the pH to values that are frequently detected in tumors causes reversible anergy in both human and mouse CD8(+) T lymphocytes in vitro. The same occurs in vivo, in the tumor microenvironment and the administration of proton pump inhibitors, which buffer tumor acidity, can revert T-cell anergy and increase the efficacy of immunotherapy. Landes Bioscience 2013-01-01 /pmc/articles/PMC3583905/ /pubmed/23483769 http://dx.doi.org/10.4161/onci.22058 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Bellone, Matteo
Calcinotto, Arianna
Filipazzi, Paola
De Milito, Angelo
Fais, Stefano
Rivoltini, Licia
The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors
title The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors
title_full The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors
title_fullStr The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors
title_full_unstemmed The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors
title_short The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors
title_sort acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583905/
https://www.ncbi.nlm.nih.gov/pubmed/23483769
http://dx.doi.org/10.4161/onci.22058
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