Targeting PI3Kδ: One man’s meat is another man’s poison

We have recently uncovered the indispensable role of phosphoinositide-3-kinase δ (PI3Kδ) at different stages of the canonical killing pathway of cytotoxic T lymphocytes (CTLs). The interception of PI3Kδ−conveyed signals has been considered a valuable therapeutic strategy in oncology. However, our ob...

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Detalles Bibliográficos
Autores principales: Prchal-Murphy, Michaela, Putz, Eva Maria, Freissmuth, Michael, Sexl, Veronika, Zebedin-Brandl, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583912/
https://www.ncbi.nlm.nih.gov/pubmed/23482629
http://dx.doi.org/10.4161/onci.22272
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author Prchal-Murphy, Michaela
Putz, Eva Maria
Freissmuth, Michael
Sexl, Veronika
Zebedin-Brandl, Eva
author_facet Prchal-Murphy, Michaela
Putz, Eva Maria
Freissmuth, Michael
Sexl, Veronika
Zebedin-Brandl, Eva
author_sort Prchal-Murphy, Michaela
collection PubMed
description We have recently uncovered the indispensable role of phosphoinositide-3-kinase δ (PI3Kδ) at different stages of the canonical killing pathway of cytotoxic T lymphocytes (CTLs). The interception of PI3Kδ−conveyed signals has been considered a valuable therapeutic strategy in oncology. However, our observations predict that the benefits of this approach may be limited by a trade-off between direct anticancer effects and an impaired ability of CTLs and NK cells to attack tumor cells.
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spelling pubmed-35839122013-03-11 Targeting PI3Kδ: One man’s meat is another man’s poison Prchal-Murphy, Michaela Putz, Eva Maria Freissmuth, Michael Sexl, Veronika Zebedin-Brandl, Eva Oncoimmunology Author's View We have recently uncovered the indispensable role of phosphoinositide-3-kinase δ (PI3Kδ) at different stages of the canonical killing pathway of cytotoxic T lymphocytes (CTLs). The interception of PI3Kδ−conveyed signals has been considered a valuable therapeutic strategy in oncology. However, our observations predict that the benefits of this approach may be limited by a trade-off between direct anticancer effects and an impaired ability of CTLs and NK cells to attack tumor cells. Landes Bioscience 2013-01-01 /pmc/articles/PMC3583912/ /pubmed/23482629 http://dx.doi.org/10.4161/onci.22272 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Prchal-Murphy, Michaela
Putz, Eva Maria
Freissmuth, Michael
Sexl, Veronika
Zebedin-Brandl, Eva
Targeting PI3Kδ: One man’s meat is another man’s poison
title Targeting PI3Kδ: One man’s meat is another man’s poison
title_full Targeting PI3Kδ: One man’s meat is another man’s poison
title_fullStr Targeting PI3Kδ: One man’s meat is another man’s poison
title_full_unstemmed Targeting PI3Kδ: One man’s meat is another man’s poison
title_short Targeting PI3Kδ: One man’s meat is another man’s poison
title_sort targeting pi3kδ: one man’s meat is another man’s poison
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583912/
https://www.ncbi.nlm.nih.gov/pubmed/23482629
http://dx.doi.org/10.4161/onci.22272
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