Hypoxia-driven immunosuppression contributes to the pre-metastatic niche

Primary tumor cells create favorable microenvironments in secondary organs, termed pre-metastatic niches, that promote the formation of metastases. Using immune competent syngenic breast cancer mouse models, we have recently demonstrated that factors secreted by hypoxic tumor cells condition pre-met...

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Detalles Bibliográficos
Autores principales: Sceneay, Jaclyn, Parker, Belinda S., Smyth, Mark J., Möller, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583916/
https://www.ncbi.nlm.nih.gov/pubmed/23482904
http://dx.doi.org/10.4161/onci.22355
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author Sceneay, Jaclyn
Parker, Belinda S.
Smyth, Mark J.
Möller, Andreas
author_facet Sceneay, Jaclyn
Parker, Belinda S.
Smyth, Mark J.
Möller, Andreas
author_sort Sceneay, Jaclyn
collection PubMed
description Primary tumor cells create favorable microenvironments in secondary organs, termed pre-metastatic niches, that promote the formation of metastases. Using immune competent syngenic breast cancer mouse models, we have recently demonstrated that factors secreted by hypoxic tumor cells condition pre-metastatic niches by recruiting CD11b(+)/Ly6C(med)/Ly6G(+) myeloid cells and suppressing natural killer cell functions.
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spelling pubmed-35839162013-03-11 Hypoxia-driven immunosuppression contributes to the pre-metastatic niche Sceneay, Jaclyn Parker, Belinda S. Smyth, Mark J. Möller, Andreas Oncoimmunology Author's View Primary tumor cells create favorable microenvironments in secondary organs, termed pre-metastatic niches, that promote the formation of metastases. Using immune competent syngenic breast cancer mouse models, we have recently demonstrated that factors secreted by hypoxic tumor cells condition pre-metastatic niches by recruiting CD11b(+)/Ly6C(med)/Ly6G(+) myeloid cells and suppressing natural killer cell functions. Landes Bioscience 2013-01-01 /pmc/articles/PMC3583916/ /pubmed/23482904 http://dx.doi.org/10.4161/onci.22355 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Sceneay, Jaclyn
Parker, Belinda S.
Smyth, Mark J.
Möller, Andreas
Hypoxia-driven immunosuppression contributes to the pre-metastatic niche
title Hypoxia-driven immunosuppression contributes to the pre-metastatic niche
title_full Hypoxia-driven immunosuppression contributes to the pre-metastatic niche
title_fullStr Hypoxia-driven immunosuppression contributes to the pre-metastatic niche
title_full_unstemmed Hypoxia-driven immunosuppression contributes to the pre-metastatic niche
title_short Hypoxia-driven immunosuppression contributes to the pre-metastatic niche
title_sort hypoxia-driven immunosuppression contributes to the pre-metastatic niche
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583916/
https://www.ncbi.nlm.nih.gov/pubmed/23482904
http://dx.doi.org/10.4161/onci.22355
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AT mollerandreas hypoxiadrivenimmunosuppressioncontributestothepremetastaticniche

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