Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediated hematopoietic stem cell toxicity

The clinical use of lymphocytes engineered to express high affinity T-cell receptors (TCRs) specific for two broadly expressed tumor-associated antigens is strongly limited by MHC-restricted fratricide of lymphocytes and TCR-mediated killing of hematopoietic stem cells. Specific clinical application...

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Detalles Bibliográficos
Autores principales: Schendel, Dolores J., Frankenberger, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583918/
https://www.ncbi.nlm.nih.gov/pubmed/23483031
http://dx.doi.org/10.4161/onci.22410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583918/
https://www.ncbi.nlm.nih.gov/pubmed/23483031
http://dx.doi.org/10.4161/onci.22410

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