Cargando…

Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediated hematopoietic stem cell toxicity

The clinical use of lymphocytes engineered to express high affinity T-cell receptors (TCRs) specific for two broadly expressed tumor-associated antigens is strongly limited by MHC-restricted fratricide of lymphocytes and TCR-mediated killing of hematopoietic stem cells. Specific clinical application...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schendel, Dolores J., Frankenberger, Bernhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2013
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583918/ https://www.ncbi.nlm.nih.gov/pubmed/23483031 http://dx.doi.org/10.4161/onci.22410

Ejemplares similares

NK-cell fratricide: Dynamic crosstalk between NK and cancer cells
por: Nakamura, Kyohei, et al.
Publicado: (2013)

A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy
por: Kobayashi, Eiji, et al.
Publicado: (2014)

Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies
por: Omokoko, Tana, et al.
Publicado: (2015)

Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes
por: Robert, Lidia, et al.
Publicado: (2014)

TCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity
por: Cartellieri, Marc, et al.
Publicado: (2013)

TCR–pMHC bond conformation controls TCR ligand discrimination
por: Sasmal, Dibyendu K., et al.
Publicado: (2019)

Evolution by innovation as a driving force to improve TCR-T therapies
por: Schendel, Dolores J.
Publicado: (2023)

Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes
por: Duong, Minh Ngoc, et al.
Publicado: (2019)

The Enigmatic Nature of the TCR-pMHC Interaction: Implications for CAR-T and TCR-T Engineering
por: Shevyrev, D. V., et al.
Publicado: (2022)

High-quality and high-avidity T cell clones specific for tumor-associated antigens and how to find them
por: Wilde, Susanne, et al.
Publicado: (2012)

Analyses of the TCR repertoire of MHC class II-restricted innate CD4(+) T cells
por: Kang, Byung Hyun, et al.
Publicado: (2015)

TCR/pMHC Optimized Protein crystallization Screen
por: Bulek, Anna M., et al.
Publicado: (2012)

Targeting the MHC Ligandome by Use of TCR-Like Antibodies
por: Høydahl, Lene Støkken, et al.
Publicado: (2019)

Targeting cancers through TCR-peptide/MHC interactions
por: He, Qinghua, et al.
Publicado: (2019)

Search for MHC/TCR-Like Systems in Living Organisms
por: Paganini, Julien, et al.
Publicado: (2021)

Engineering hematopoietic stem cells to create melanoma specific CTL
por: Vatakis, Dimitrios
Publicado: (2012)

Germline-Encoded TCR-MHC Contacts Promote TCR V Gene Bias in Umbilical Cord Blood T Cell Repertoire
por: Gao, Kai, et al.
Publicado: (2019)

Force Measurements of TCR/pMHC Recognition at T Cell Surface
por: Puech, Pierre-Henri, et al.
Publicado: (2011)

Genome-wide structural modelling of TCR-pMHC interactions
por: Liu, I-Hsin, et al.
Publicado: (2013)

TCR/pMHC Interaction: Phenotypic Model for an Unsolved Enigma
por: Gálvez, Jesús, et al.
Publicado: (2016)

Integrating Experiment and Theory to Understand TCR-pMHC Dynamics
por: Buckle, Ashley M., et al.
Publicado: (2018)

TCR‐induced alteration of primary MHC peptide anchor residue
por: Madura, Florian, et al.
Publicado: (2019)

Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules
por: Krovi, S. Harsha, et al.
Publicado: (2019)

TCR Recognition of Peptide–MHC-I: Rule Makers and Breakers
por: Szeto, Christopher, et al.
Publicado: (2020)

Rapid screening of TCR-pMHC interactions by the YAMTAD system
por: Wang, Lihui, et al.
Publicado: (2022)

Information-Driven Docking for TCR-pMHC Complex Prediction
por: Peacock, Thomas, et al.
Publicado: (2021)

Human TCR-gamma+/delta+, CD8+ T lymphocytes recognize tetanus toxoid in an MHC-restricted fashion
Publicado: (1989)

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry
por: Singh, Nishant K., et al.
Publicado: (2022)

MHC-I genotype drives early immune selection of oncogenic mutations
por: Marty, Rachel, et al.
Publicado: (2018)

Corrigendum: Germline-Encoded TCR-MHC Contacts Promote TCR V Gene Bias in Umbilical Cord Blood T Cell Repertoire
por: Gao, Kai, et al.
Publicado: (2020)

Potent T cell agonism mediated by a very rapid TCR/pMHC interaction
por: Boulter, Jonathan M, et al.
Publicado: (2007)

Myeloid-derived suppressor cells in allogeneic hematopoietic stem cell transplantation: A double-edged sword?
por: Le Blanc, Katarina, et al.
Publicado: (2013)

Non-classical MHC Class I molecules regulating natural killer cell function
por: Smyth, Mark J., et al.
Publicado: (2013)

Invariant natural killer T cells reconstitution and the control of leukemia relapse in pediatric haploidentical hematopoietic stem cell transplantation
por: Casorati, Giulia, et al.
Publicado: (2012)

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide–MHC
por: Hoerter, John A.H., et al.
Publicado: (2013)

Regulatory T cells and co‐evolution of allele‐specific MHC recognition by the TCR
por: Steele, Edward J., et al.
Publicado: (2019)

Hybrid gMLP model for interaction prediction of MHC-peptide and TCR
por: Zhang, Lichao, et al.
Publicado: (2023)

n-3 Polyunsaturated Fatty Acids Impede the TCR Mobility and the TCR–pMHC Interaction of Anti-Viral CD8(+) T Cells
por: Lim, Younghyun, et al.
Publicado: (2020)

An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity
por: Maus, Marcela V, et al.
Publicado: (2017)

Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development
por: Borowski, Christine, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_eiru8jcaakqg5bc36e1m1r7nph