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T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment
Recently, we reported the accumulation of CD4(+)FOXP3(+) regulatory T cells (Tregs) within the tumor mass of patients bearing liver cancer. Tumor-infiltrating Tregs (TiTregs) are active and potent suppressors of antitumor immunity. Importantly, treatment with GITRL reduced the immunosuppression medi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583921/ https://www.ncbi.nlm.nih.gov/pubmed/23483229 http://dx.doi.org/10.4161/onci.22450 |