T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment

Recently, we reported the accumulation of CD4(+)FOXP3(+) regulatory T cells (Tregs) within the tumor mass of patients bearing liver cancer. Tumor-infiltrating Tregs (TiTregs) are active and potent suppressors of antitumor immunity. Importantly, treatment with GITRL reduced the immunosuppression medi...

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Detalles Bibliográficos
Autores principales: Pedroza-Gonzalez, Alexander, Kwekkeboom, Jaap, Sprengers, Dave
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583921/
https://www.ncbi.nlm.nih.gov/pubmed/23483229
http://dx.doi.org/10.4161/onci.22450
Descripción
Sumario:Recently, we reported the accumulation of CD4(+)FOXP3(+) regulatory T cells (Tregs) within the tumor mass of patients bearing liver cancer. Tumor-infiltrating Tregs (TiTregs) are active and potent suppressors of antitumor immunity. Importantly, treatment with GITRL reduced the immunosuppression mediated by TiTregs.

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