T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment

Recently, we reported the accumulation of CD4(+)FOXP3(+) regulatory T cells (Tregs) within the tumor mass of patients bearing liver cancer. Tumor-infiltrating Tregs (TiTregs) are active and potent suppressors of antitumor immunity. Importantly, treatment with GITRL reduced the immunosuppression medi...

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Detalles Bibliográficos
Autores principales: Pedroza-Gonzalez, Alexander, Kwekkeboom, Jaap, Sprengers, Dave
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583921/
https://www.ncbi.nlm.nih.gov/pubmed/23483229
http://dx.doi.org/10.4161/onci.22450
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author Pedroza-Gonzalez, Alexander
Kwekkeboom, Jaap
Sprengers, Dave
author_facet Pedroza-Gonzalez, Alexander
Kwekkeboom, Jaap
Sprengers, Dave
author_sort Pedroza-Gonzalez, Alexander
collection PubMed
description Recently, we reported the accumulation of CD4(+)FOXP3(+) regulatory T cells (Tregs) within the tumor mass of patients bearing liver cancer. Tumor-infiltrating Tregs (TiTregs) are active and potent suppressors of antitumor immunity. Importantly, treatment with GITRL reduced the immunosuppression mediated by TiTregs.
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spelling pubmed-35839212013-03-11 T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment Pedroza-Gonzalez, Alexander Kwekkeboom, Jaap Sprengers, Dave Oncoimmunology Author's View Recently, we reported the accumulation of CD4(+)FOXP3(+) regulatory T cells (Tregs) within the tumor mass of patients bearing liver cancer. Tumor-infiltrating Tregs (TiTregs) are active and potent suppressors of antitumor immunity. Importantly, treatment with GITRL reduced the immunosuppression mediated by TiTregs. Landes Bioscience 2013-01-01 /pmc/articles/PMC3583921/ /pubmed/23483229 http://dx.doi.org/10.4161/onci.22450 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Pedroza-Gonzalez, Alexander
Kwekkeboom, Jaap
Sprengers, Dave
T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment
title T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment
title_full T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment
title_fullStr T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment
title_full_unstemmed T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment
title_short T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment
title_sort t-cell suppression mediated by regulatory t cells infiltrating hepatic tumors can be overcome by gitrl treatment
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583921/
https://www.ncbi.nlm.nih.gov/pubmed/23483229
http://dx.doi.org/10.4161/onci.22450
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AT kwekkeboomjaap tcellsuppressionmediatedbyregulatorytcellsinfiltratinghepatictumorscanbeovercomebygitrltreatment
AT sprengersdave tcellsuppressionmediatedbyregulatorytcellsinfiltratinghepatictumorscanbeovercomebygitrltreatment

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