Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

BACKGROUND: Long-term and unresolved airway inflammation and airway remodeling, characteristic features of chronic asthma, if not treated could lead to permanent structural changes in the airways. Aldose reductase (AR), an aldo-sugar and lipid aldehyde metabolizing enzyme, mediates allergen-induced...

Descripción completa

Detalles Bibliográficos
Autores principales: Yadav, Umesh C. S., Naura, Amarjit S., Aguilera-Aguirre, Leopoldo, Boldogh, Istvan, Boulares, Hamid A., Calhoun, William J., Ramana, Kota V., Srivastava, Satish K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584054/
https://www.ncbi.nlm.nih.gov/pubmed/23460857
http://dx.doi.org/10.1371/journal.pone.0057442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584054/
https://www.ncbi.nlm.nih.gov/pubmed/23460857
http://dx.doi.org/10.1371/journal.pone.0057442

Ejemplares similares