Conformational and Thermal Stability Improvements for the Large-Scale Production of Yeast-Derived Rabbit Hemorrhagic Disease Virus-Like Particles as Multipurpose Vaccine

Recombinant virus-like particles (VLP) antigenically similar to rabbit hemorrhagic disease virus (RHDV) were recently expressed at high levels inside Pichia pastoris cells. Based on the potential of RHDV VLP as platform for diverse vaccination purposes we undertook the design, development and scale-...

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Detalles Bibliográficos
Autores principales: Fernández, Erlinda, Toledo, Jorge R., Méndez, Lídice, González, Nemecio, Parra, Francisco, Martín-Alonso, José M., Limonta, Miladys, Sánchez, Kosara, Cabrales, Ania, Estrada, Mario P., Rodríguez-Mallón, Alina, Farnós, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584067/
https://www.ncbi.nlm.nih.gov/pubmed/23460801
http://dx.doi.org/10.1371/journal.pone.0056417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584067/
https://www.ncbi.nlm.nih.gov/pubmed/23460801
http://dx.doi.org/10.1371/journal.pone.0056417

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