The Interaction of the Chemotherapeutic Drug Chlorambucil with Human Glutathione Transferase A1-1: Kinetic and Structural Analysis

Glutathione transferases (GSTs) are enzymes that contribute to cellular detoxification by catalysing the nucleophilic attack of glutathione (GSH) on the electrophilic centre of a number of xenobiotic compounds, including several chemotherapeutic drugs. In the present work we investigated the interac...

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Detalles Bibliográficos
Autores principales: Karpusas, Michael, Axarli, Irine, Chiniadis, Lykourgos, Papakyriakou, Athanasios, Bethanis, Kostas, Scopelitou, Katholiki, Clonis, Yannis D., Labrou, Nikolaos E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584069/
https://www.ncbi.nlm.nih.gov/pubmed/23460799
http://dx.doi.org/10.1371/journal.pone.0056337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584069/
https://www.ncbi.nlm.nih.gov/pubmed/23460799
http://dx.doi.org/10.1371/journal.pone.0056337

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