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MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA

Maintenance of genetic stability is crucial for all organisms in order to avoid the onset of deleterious diseases such as cancer. One of the many proveniences of DNA base damage in mammalian cells is oxidative stress, arising from a variety of endogenous and exogenous sources, generating highly muta...

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Detalles Bibliográficos
Autores principales: Markkanen, Enni, Dorn, Julia, Hübscher, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584444/
https://www.ncbi.nlm.nih.gov/pubmed/23450852
http://dx.doi.org/10.3389/fgene.2013.00018