Cargando…

Characterization and rescue of telomeric abnormalities in ICF syndrome type I fibroblasts

Mutations in the human DNA methyltransferase 3B (DNMT3B) gene lead to ICF (immunodeficiency, centromeric region instability, and facial anomalies) syndrome type I. We have previously described a telomere-related phenotype in cells from these patients, involving severe hypomethylation of subtelomeric...

Descripción completa

Detalles Bibliográficos
Autores principales: Yehezkel, Shiran, Shaked, Rony, Sagie, Shira, Berkovitz, Ron, Shachar-Bener, Hofit, Segev, Yardena, Selig, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584450/
https://www.ncbi.nlm.nih.gov/pubmed/23450006
http://dx.doi.org/10.3389/fonc.2013.00035