HIF-2α Suppresses p53 to Enhance the Stemness and Regenerative Potential of Human Embryonic Stem Cells

Human embryonic stem cells (hESCs) have been reported to exert cytoprotective activity in the area of tissue injury. However, hypoxia/oxidative stress prevailing in the area of injury could activate p53, leading to death and differentiation of hESCs. Here we report that when exposed to hypoxia/oxida...

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Detalles Bibliográficos
Autores principales: Das, Bikul, Bayat-Mokhtari, Reza, Tsui, Micky, Lotfi, Shamim, Tsuchida, Rika, Felsher, Dean W, Yeger, Herman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2012
Materias:
Regenerative Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584519/
https://www.ncbi.nlm.nih.gov/pubmed/22689594
http://dx.doi.org/10.1002/stem.1142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584519/
https://www.ncbi.nlm.nih.gov/pubmed/22689594
http://dx.doi.org/10.1002/stem.1142

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