Cargando…

HIF-2α Suppresses p53 to Enhance the Stemness and Regenerative Potential of Human Embryonic Stem Cells

Human embryonic stem cells (hESCs) have been reported to exert cytoprotective activity in the area of tissue injury. However, hypoxia/oxidative stress prevailing in the area of injury could activate p53, leading to death and differentiation of hESCs. Here we report that when exposed to hypoxia/oxida...

Descripción completa

Detalles Bibliográficos
Autores principales:	Das, Bikul, Bayat-Mokhtari, Reza, Tsui, Micky, Lotfi, Shamim, Tsuchida, Rika, Felsher, Dean W, Yeger, Herman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wiley Subscription Services, Inc., A Wiley Company 2012
Materias:	Regenerative Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584519/ https://www.ncbi.nlm.nih.gov/pubmed/22689594 http://dx.doi.org/10.1002/stem.1142

Ejemplares similares

Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma
por: Bayat Mokhtari, Reza, et al.
Publicado: (2017)

3D Multicellular Stem-Like Human Breast Tumor Spheroids Enhance Tumorigenicity of Orthotopic Xenografts in Athymic Nude Rat Model
por: Mokhtari, Reza Bayat, et al.
Publicado: (2021)

Combination therapy in combating cancer
por: Mokhtari, Reza Bayat, et al.
Publicado: (2017)

Allogeneic adipose‐derived stem cells promote ischemic muscle repair by inducing M2 macrophage polarization via the HIF‐1α/IL‐10 pathway
por: Liu, Junchao, et al.
Publicado: (2020)

Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel From Embryonic Stem Cell‐Derived Self‐Forming Retina
por: Lakowski, Jorn, et al.
Publicado: (2015)

Concise Review: The Regenerative Journey of Pericytes Toward Clinical Translation
por: Cathery, William, et al.
Publicado: (2018)

Ultrasound-Assisted Liposuction Does Not Compromise the Regenerative Potential of Adipose-Derived Stem Cells
por: Duscher, Dominik, et al.
Publicado: (2016)

Stem Cells and Cartilage Development: Complexities of a Simple Tissue
por: Hollander, Anthony P, et al.
Publicado: (2010)

Allogeneic Periodontal Ligament Stem Cell Therapy for Periodontitis in Swine
por: Ding, Gang, et al.
Publicado: (2010)

In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras
por: Wen, Bingqiang, et al.
Publicado: (2022)

Preclinical safety studies of human embryonic stem cell‐derived retinal pigment epithelial cells for the treatment of age‐related macular degeneration
por: Petrus‐Reurer, Sandra, et al.
Publicado: (2020)

Pluripotent stem cell‐derived retinal organoids for disease modeling and development of therapies
por: Kruczek, Kamil, et al.
Publicado: (2020)

Application of Tonsil‐Derived Mesenchymal Stem Cells in Tissue Regeneration: Concise Review
por: Oh, Se‐Young, et al.
Publicado: (2019)

Mouse embryonic stem cells can differentiate via multiple paths to the same state
por: Briggs, James Alexander, et al.
Publicado: (2017)

Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium
por: Korkka, Iina, et al.
Publicado: (2022)

Impaired Bone Regenerative Effect of Exosomes Derived from Bone Marrow Mesenchymal Stem Cells in Type 1 Diabetes
por: Zhu, Yu, et al.
Publicado: (2019)

Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation
por: LeBlanc, Lucy, et al.
Publicado: (2018)

Inhibition of T Cell Protein Tyrosine Phosphatase Enhances Interleukin-18-Dependent Hematopoietic Stem Cell Expansion
por: Bourdeau, Annie, et al.
Publicado: (2013)

Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation
por: Tassoni, Alessia, et al.
Publicado: (2015)

Enhanced Function of Induced Pluripotent Stem Cell‐Derived Endothelial Cells Through ESM1 Signaling
por: Vilà‐González, Marta, et al.
Publicado: (2018)

In Utero Transplantation of Expanded Autologous Amniotic Fluid Stem Cells Results in Long‐Term Hematopoietic Engraftment
por: Loukogeorgakis, Stavros P., et al.
Publicado: (2019)

Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells
por: Mullen, Michael, et al.
Publicado: (2023)

Induced Pluripotent Stem Cells Restore Function in a Human Cell Loss Model of Open-Angle Glaucoma
por: Abu-Hassan, Diala W, et al.
Publicado: (2015)

Neuroprotective Effects of Human Mesenchymal Stem Cells and Platelet‐Derived Growth Factor on Human Retinal Ganglion Cells
por: Osborne, Andrew, et al.
Publicado: (2017)

Concise Review: Reduction of Adverse Cardiac Scarring Facilitates Pluripotent Stem Cell‐Based Therapy for Myocardial Infarction
por: Liang, Jialiang, et al.
Publicado: (2019)

Highly Purified Human Extracellular Vesicles Produced by Stem Cells Alleviate Aging Cellular Phenotypes of Senescent Human Cells
por: Liu, Senquan, et al.
Publicado: (2019)

Human bronchial carcinoid tumor initiating cells are targeted by the combination of acetazolamide and sulforaphane
por: Bayat Mokhtari, Reza, et al.
Publicado: (2019)

Human placenta mesenchymal stem cell protection in ischemic stroke is angiotensin converting enzyme‐2 and masR receptor‐dependent
por: Barzegar, Mansoureh, et al.
Publicado: (2021)

Cadherin-11 Influences Differentiation in Human Mesenchymal Stem Cells by Regulating the Extracellular Matrix Via the TGFβ1 Pathway
por: Passanha, Fiona R, et al.
Publicado: (2022)

Neuroprotective Effects of Genome-Edited Human iPS Cell-Derived Neural Stem/Progenitor Cells on Traumatic Brain Injury
por: Imai, Ryotaro, et al.
Publicado: (2023)

Pharmacological Modulation of Human Mesenchymal Stem Cell Chondrogenesis by a Chemically Oversulfated Polysaccharide of Marine Origin: Potential Application to Cartilage Regenerative Medicine
por: Merceron, Christophe, et al.
Publicado: (2012)

Functional Voltage‐Gated Calcium Channels Are Present in Human Embryonic Stem Cell‐Derived Retinal Pigment Epithelium
por: Korkka, Iina, et al.
Publicado: (2018)

Coronavirus Activates an Altruistic Stem Cell–Mediated Defense Mechanism that Reactivates Dormant Tuberculosis: Implications in Coronavirus Disease 2019 Pandemic
por: Pathak, Lekhika, et al.
Publicado: (2021)

Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell‐Derived Retinal Organoids and Fetal Retinae
por: Lakowski, Jörn, et al.
Publicado: (2018)

The Next-Generation of Combination Cancer Immunotherapy: Epigenetic Immunomodulators Transmogrify Immune Training to Enhance Immunotherapy
por: Mokhtari, Reza Bayat, et al.
Publicado: (2021)

Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense
por: Bhuyan, Seema, et al.
Publicado: (2022)

Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice
por: Yungher, Benjamin J., et al.
Publicado: (2017)

The repair and autophagy mechanisms of hypoxia‐regulated bFGF‐modified primary embryonic neural stem cells in spinal cord injury
por: Zhu, Sipin, et al.
Publicado: (2020)

Concise Review: Stem/Progenitor Cell Proteoglycans Decorated with 7‐D‐4, 4‐C‐3, and 3‐B‐3(‐) Chondroitin Sulfate Motifs Are Morphogenetic Markers of Tissue Development
por: Hayes, Anthony J., et al.
Publicado: (2018)

Implantation of the clinical‐grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid‐lesioned rodent model of Huntington's disease
por: Yoon, Yongwoo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fmhodc560kagu8bu67ci6tc6q5