Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells

The specific 26S proteasome inhibitor, bortezomib (BZ) potently induces apoptosis as well as autophagy in metastatic breast cancer cell lines such as MDA-MB-231 and MDA-MB-468. The combined treatment of clarithromycin (CAM) and BZ significantly enhances cytotoxicity in these cell lines. Although tre...

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Detalles Bibliográficos
Autores principales: KOMATSU, SEIICHIRO, MIYAZAWA, KEISUKE, MORIYA, SHOTA, TAKASE, AKIKO, NAITO, MUNEKAZU, INAZU, MASATO, KOHNO, NORIO, ITOH, MASAHIRO, TOMODA, AKIO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584821/
https://www.ncbi.nlm.nih.gov/pubmed/22200786
http://dx.doi.org/10.3892/ijo.2011.1317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584821/
https://www.ncbi.nlm.nih.gov/pubmed/22200786
http://dx.doi.org/10.3892/ijo.2011.1317

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