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Quantitative Analysis of Histone Modifications: Formaldehyde Is a Source of Pathological N(6)-Formyllysine That Is Refractory to Histone Deacetylases
Aberrant protein modifications play an important role in the pathophysiology of many human diseases, in terms of both dysfunction of physiological modifications and the formation of pathological modifications by reaction of proteins with endogenous electrophiles. Recent studies have identified a che...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585032/ https://www.ncbi.nlm.nih.gov/pubmed/23468656 http://dx.doi.org/10.1371/journal.pgen.1003328 |