Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency

Large-scale population sequencing studies provide a complete picture of human genetic variation within the studied populations. A key challenge is to identify, among the myriad alleles, those variants that have an effect on molecular function, phenotypes, and reproductive fitness. Most non-neutral v...

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Detalles Bibliográficos
Autores principales: Kiezun, Adam, Pulit, Sara L., Francioli, Laurent C., van Dijk, Freerk, Swertz, Morris, Boomsma, Dorret I., van Duijn, Cornelia M., Slagboom, P. Eline, van Ommen, G. J. B., Wijmenga, Cisca, de Bakker, Paul I. W., Sunyaev, Shamil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585140/
https://www.ncbi.nlm.nih.gov/pubmed/23468643
http://dx.doi.org/10.1371/journal.pgen.1003301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585140/
https://www.ncbi.nlm.nih.gov/pubmed/23468643
http://dx.doi.org/10.1371/journal.pgen.1003301

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