Sustained Activation of Akt Elicits Mitochondrial Dysfunction to Block Plasmodium falciparum Infection in the Mosquito Host

The overexpression of activated, myristoylated Akt in the midgut of female transgenic Anopheles stephensi results in resistance to infection with the human malaria parasite Plasmodium falciparum but also decreased lifespan. In the present study, the understanding of mitochondria-dependent midgut hom...

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Detalles Bibliográficos
Autores principales: Luckhart, Shirley, Giulivi, Cecilia, Drexler, Anna L., Antonova-Koch, Yevgeniya, Sakaguchi, Danielle, Napoli, Eleonora, Wong, Sarah, Price, Mark S., Eigenheer, Richard, Phinney, Brett S., Pakpour, Nazzy, Pietri, Jose E., Cheung, Kong, Georgis, Martha, Riehle, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585164/
https://www.ncbi.nlm.nih.gov/pubmed/23468624
http://dx.doi.org/10.1371/journal.ppat.1003180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585164/
https://www.ncbi.nlm.nih.gov/pubmed/23468624
http://dx.doi.org/10.1371/journal.ppat.1003180

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