The C-Terminal Region Mesd Peptide Mimics Full-Length Mesd and Acts as an Inhibitor of Wnt/β-Catenin Signaling in Cancer Cells

While Mesd was discovered as a specialized molecular endoplasmic reticulum chaperone for the Wnt co-receptors LRP5 and LRP6, recombinant Mesd protein is able to bind to mature LRP5 and LRP6 on the cell surface and acts as a universal antagonist of LRP5/6 modulators. In our previous study, we found t...

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Detalles Bibliográficos
Autores principales: Lin, Cuihong, Lu, Wenyan, Zhang, Wei, Londoño-Joshi, Angelina I., Buchsbaum, Donald J., Bu, Guojun, Li, Yonghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585277/
https://www.ncbi.nlm.nih.gov/pubmed/23469146
http://dx.doi.org/10.1371/journal.pone.0058102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585277/
https://www.ncbi.nlm.nih.gov/pubmed/23469146
http://dx.doi.org/10.1371/journal.pone.0058102

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