The Selective Phosphodiesterase 4 Inhibitor Roflumilast and Phosphodiesterase 3/4 Inhibitor Pumafentrine Reduce Clinical Score and TNF Expression in Experimental Colitis in Mice

OBJECTIVE: The specific inhibition of phosphodiesterase (PDE)4 and dual inhibition of PDE3 and PDE4 has been shown to decrease inflammation by suppression of pro-inflammatory cytokine synthesis. We examined the effect of roflumilast, a selective PDE4 inhibitor marketed for severe COPD, and the inves...

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Detalles Bibliográficos
Autores principales: Rieder, Florian, Siegmund, Britta, Bundschuh, Daniela S., Lehr, Hans-Anton, Endres, Stefan, Eigler, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585290/
https://www.ncbi.nlm.nih.gov/pubmed/23468885
http://dx.doi.org/10.1371/journal.pone.0056867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585290/
https://www.ncbi.nlm.nih.gov/pubmed/23468885
http://dx.doi.org/10.1371/journal.pone.0056867

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