Effects of Sertraline and Fluoxetine on P-Glycoprotein at Barrier Sites: In Vivo and In Vitro Approaches

BACKGROUND AND PURPOSE: Retention of substances from systemic circulation in the brain and testes are limited due to high levels of P-glycoprotein (P-gp) in the luminal membranes of brain and testes capillary endothelial cells. From a clinical perspective, P-gp rapidly extrudes lipophilic therapeuti...

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Detalles Bibliográficos
Autores principales: Kapoor, Amita, Iqbal, Majid, Petropoulos, Sophie, Ho, Hay Lam, Gibb, William, Matthews, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585317/
https://www.ncbi.nlm.nih.gov/pubmed/23468867
http://dx.doi.org/10.1371/journal.pone.0056525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585317/
https://www.ncbi.nlm.nih.gov/pubmed/23468867
http://dx.doi.org/10.1371/journal.pone.0056525

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