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A Protein Turnover Signaling Motif Controls the Stimulus-Sensitivity of Stress Response Pathways

Stimulus-induced perturbations from the steady state are a hallmark of signal transduction. In some signaling modules, the steady state is characterized by rapid synthesis and degradation of signaling proteins. Conspicuous among these are the p53 tumor suppressor, its negative regulator Mdm2, and th...

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Detalles Bibliográficos
Autores principales: Loriaux, Paul Michael, Hoffmann, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585401/
https://www.ncbi.nlm.nih.gov/pubmed/23468615
http://dx.doi.org/10.1371/journal.pcbi.1002932