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A Protein Turnover Signaling Motif Controls the Stimulus-Sensitivity of Stress Response Pathways
Stimulus-induced perturbations from the steady state are a hallmark of signal transduction. In some signaling modules, the steady state is characterized by rapid synthesis and degradation of signaling proteins. Conspicuous among these are the p53 tumor suppressor, its negative regulator Mdm2, and th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585401/ https://www.ncbi.nlm.nih.gov/pubmed/23468615 http://dx.doi.org/10.1371/journal.pcbi.1002932 |