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Site-Specific Interaction between α-Synuclein and Membranes Probed by NMR-Observed Methionine Oxidation Rates

[Image: see text] α-Synuclein (αS) is an intrinsically disordered protein that is water-soluble but also can bind negatively charged lipid membranes while adopting an α-helical conformation. Membrane affinity is increased by post-translational N-terminal acetylation, a common modification in all euk...

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Detalles Bibliográficos
Autores principales: Maltsev, Alexander S., Chen, Jue, Levine, Rodney L., Bax, Ad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585462/
https://www.ncbi.nlm.nih.gov/pubmed/23398174
http://dx.doi.org/10.1021/ja312415q