Cargando…

Site-Specific Interaction between α-Synuclein and Membranes Probed by NMR-Observed Methionine Oxidation Rates

[Image: see text] α-Synuclein (αS) is an intrinsically disordered protein that is water-soluble but also can bind negatively charged lipid membranes while adopting an α-helical conformation. Membrane affinity is increased by post-translational N-terminal acetylation, a common modification in all euk...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maltsev, Alexander S., Chen, Jue, Levine, Rodney L., Bax, Ad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2013
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585462/ https://www.ncbi.nlm.nih.gov/pubmed/23398174 http://dx.doi.org/10.1021/ja312415q

Ejemplares similares

Differential Phospholipid Binding of α-Synuclein Variants Implicated in Parkinson’s Disease Revealed by Solution NMR Spectroscopy
por: Bodner, Christina R., et al.
Publicado: (2009)

Monomeric α-Synuclein Binds Congo Red Micelles in a Disordered Manner
por: Maltsev, Alexander S., et al.
Publicado: (2011)

Impact of N-Terminal Acetylation of α-Synuclein on Its Random Coil and Lipid Binding Properties
por: Maltsev, Alexander S., et al.
Publicado: (2012)

Nuclear Magnetic Resonance Observation of α-Synuclein Membrane Interaction by Monitoring the Acetylation Reactivity of Its Lysine Side Chains
por: Lee, Jung Ho, et al.
Publicado: (2016)

Dopamine-Mediated Oxidation of Methionine 127 in α-Synuclein Causes Cytotoxicity and Oligomerization of α-Synuclein
por: Nakaso, Kazuhiro, et al.
Publicado: (2013)

Metal interactions of α-synuclein probed by NMR amide-proton exchange
por: Gonzalez-Garcia, Mario, et al.
Publicado: (2023)

Decreased Phosphorylation and Increased Methionine Oxidation of α-Synuclein in the Methionine Sulfoxide Reductase A Knockout Mouse
por: Oien, Derek B., et al.
Publicado: (2011)

Erratum to “Decreased Phosphorylation and Increased Methionine Oxidation of α-Synuclein in the Methionine Sulfoxide Reductase A Knockout Mouse”
por: Oien, Derek B., et al.
Publicado: (2012)

Unroofing site-specific α-synuclein–lipid interactions at the plasma membrane
por: Kaur, Upneet, et al.
Publicado: (2020)

Membrane Interactions of α-Synuclein Revealed by Multiscale Molecular Dynamics Simulations, Markov State Models, and NMR
por: Amos, Sarah-Beth T. A., et al.
Publicado: (2021)

NMR Observation of Sulfhydryl Signals in SARS‐CoV‐2 Main Protease Aids Structural Studies
por: Robertson, Angus J., et al.
Publicado: (2022)

Probing Membrane Association of α-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding Pattern
por: Jacobs, Daniel, et al.
Publicado: (2019)

Mechanistic Insight into the Relationship between N-Terminal Acetylation of α-Synuclein and Fibril Formation Rates by NMR and Fluorescence
por: Kang, Lijuan, et al.
Publicado: (2013)

Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies
por: Cascella, Roberta, et al.
Publicado: (2019)

Oxidation of Methionine 77 in Calmodulin Alters Mouse Growth and Behavior
por: Marimoutou, Méry, et al.
Publicado: (2018)

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation
por: Scheibe, Christian, et al.
Publicado: (2021)

Cooperativity of α-Synuclein Binding to Lipid Membranes
por: Makasewicz, Katarzyna, et al.
Publicado: (2021)

Direct Observation of the Three Regions in α-Synuclein that Determine its Membrane-Bound Behaviour
por: Fusco, Giuliana, et al.
Publicado: (2014)

Remarkable Rigidity of the Single α-Helical Domain of Myosin-VI As Revealed by NMR Spectroscopy
por: Barnes, C. Ashley, et al.
Publicado: (2019)

Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity
por: Ysselstein, Daniel, et al.
Publicado: (2017)

Unlike Twins: An NMR Comparison of Two α-Synuclein Polymorphs Featuring Different Toxicity
por: Gath, Julia, et al.
Publicado: (2014)

The hot sites of α-synuclein in amyloid fibril formation
por: Khammari, Anahita, et al.
Publicado: (2020)

Investigation of α-Synuclein Amyloid Fibrils Using the Fluorescent Probe Thioflavin T
por: Sulatskaya, Anna I., et al.
Publicado: (2018)

Simultaneous Quantification of H(2)O(2) and Organic Hydroperoxides by (1)H NMR Spectroscopy
por: Kakeshpour, Tayeb, et al.
Publicado: (2022)

Synergism between x-ray crystallography and NMR residual dipolar couplings in characterizing protein dynamics
por: Shen, Yang, et al.
Publicado: (2023)

Membrane Permeabilization by Oligomeric α-Synuclein: In Search of the Mechanism
por: van Rooijen, Bart D., et al.
Publicado: (2010)

Membrane Lipid Co-Aggregation with α-Synuclein Fibrils
por: Hellstrand, Erik, et al.
Publicado: (2013)

Structural and Dynamical Insights into the Membrane-Bound α-Synuclein
por: Jain, Neha, et al.
Publicado: (2013)

Plasticity of Membrane Binding by the Central Region of α-Synuclein
por: Navarro-Paya, Carlos, et al.
Publicado: (2022)

Solid-State NMR Structure of a Pathogenic Fibril of Full-Length Human α-Synuclein
por: Tuttle, Marcus D., et al.
Publicado: (2016)

Liquid Crystalline Phase of G-Tetrad DNA for NMR Study of Detergent-Solubilized Proteins
por: Lorieau, Justin, et al.
Publicado: (2008)

DNP-Enhanced MAS NMR: A Tool to Snapshot Conformational Ensembles of α-Synuclein in Different States
por: Uluca, Boran, et al.
Publicado: (2018)

Comparison of the 3D structures of mouse and human α-synuclein fibrils by solid-state NMR and STEM()
por: Hwang, Songhwan, et al.
Publicado: (2019)

Spatially resolved DNP-assisted NMR illuminates the conformational ensemble of α-synuclein in intact viable cells
por: Kragelj, Jaka, et al.
Publicado: (2023)

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
por: Ryan, Tammy, et al.
Publicado: (2018)

Structural characteristics and membrane interactions of tandem α-synuclein oligomers
por: Dong, Chunhua, et al.
Publicado: (2018)

Direct Visualization of Model Membrane Remodeling by α‐Synuclein Fibrillization
por: Chaudhary, Himanshu, et al.
Publicado: (2017)

Freezing and piercing of in vitro asymmetric plasma membrane by α-synuclein
por: Heo, Paul, et al.
Publicado: (2020)

α-Synuclein and biological membranes: the danger of loving too much
por: Mansueto, Silvia, et al.
Publicado: (2023)

Monomeric α‐synuclein activates the plasma membrane calcium pump
por: Kowalski, Antoni, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_989ovugj5ujcujut546l6rese8