Human CD3γ, but not CD3δ, haploinsufficiency differentially impairs γδ versus αβ surface TCR expression

BACKGROUND: The T cell antigen receptors (TCR) of αβ and γδ T lymphocytes are believed to assemble in a similar fashion in humans. Firstly, αβ or γδ TCR chains incorporate a CD3δε dimer, then a CD3γε dimer and finally a ζζ homodimer, resulting in TCR complexes with the same CD3 dimer stoichiometry....

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Detalles Bibliográficos
Autores principales: Muñoz-Ruiz, Miguel, Pérez-Flores, Verónica, Garcillán, Beatriz, Guardo, Alberto C, Mazariegos, Marina S, Takada, Hidetoshi, Allende, Luis M, Kilic, Sara S, Sanal, Ozden, Roifman, Chaim M, López-Granados, Eduardo, Recio, María J, Martínez-Naves, Eduardo, Fernández-Malavé, Edgar, Regueiro, José R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585704/
https://www.ncbi.nlm.nih.gov/pubmed/23336327
http://dx.doi.org/10.1186/1471-2172-14-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585704/
https://www.ncbi.nlm.nih.gov/pubmed/23336327
http://dx.doi.org/10.1186/1471-2172-14-3

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