Genome-Wide ENU Mutagenesis in Combination with High Density SNP Analysis and Exome Sequencing Provides Rapid Identification of Novel Mouse Models of Developmental Disease

BACKGROUND: Mice harbouring gene mutations that cause phenotypic abnormalities during organogenesis are invaluable tools for linking gene function to normal development and human disorders. To generate mouse models harbouring novel alleles that are involved in organogenesis we conducted a phenotype-...

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Detalles Bibliográficos
Autores principales: Caruana, Georgina, Farlie, Peter G., Hart, Adam H., Bagheri-Fam, Stefan, Wallace, Megan J., Dobbie, Michael S., Gordon, Christopher T., Miller, Kerry A., Whittle, Belinda, Abud, Helen E., Arkell, Ruth M., Cole, Timothy J., Harley, Vincent R., Smyth, Ian M., Bertram, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585849/
https://www.ncbi.nlm.nih.gov/pubmed/23469164
http://dx.doi.org/10.1371/journal.pone.0055429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585849/
https://www.ncbi.nlm.nih.gov/pubmed/23469164
http://dx.doi.org/10.1371/journal.pone.0055429

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