Impaired Mitochondrial Dynamics and Nrf2 Signaling Contribute to Compromised Responses to Oxidative Stress in Striatal Cells Expressing Full-Length Mutant Huntingtin

Huntington disease (HD) is an inherited neurodegenerative disease resulting from an abnormal expansion of polyglutamine in huntingtin (Htt). Compromised oxidative stress defense systems have emerged as a contributing factor to the pathogenesis of HD. Indeed activation of the Nrf2 pathway, which play...

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Detalles Bibliográficos
Autores principales: Jin, Youngnam N., Yu, Yanxun V., Gundemir, Soner, Jo, Chulman, Cui, Mei, Tieu, Kim, Johnson, Gail V. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585875/
https://www.ncbi.nlm.nih.gov/pubmed/23469253
http://dx.doi.org/10.1371/journal.pone.0057932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585875/
https://www.ncbi.nlm.nih.gov/pubmed/23469253
http://dx.doi.org/10.1371/journal.pone.0057932

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