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Impaired Mitochondrial Dynamics and Nrf2 Signaling Contribute to Compromised Responses to Oxidative Stress in Striatal Cells Expressing Full-Length Mutant Huntingtin
Huntington disease (HD) is an inherited neurodegenerative disease resulting from an abnormal expansion of polyglutamine in huntingtin (Htt). Compromised oxidative stress defense systems have emerged as a contributing factor to the pathogenesis of HD. Indeed activation of the Nrf2 pathway, which play...
Autores principales: | Jin, Youngnam N., Yu, Yanxun V., Gundemir, Soner, Jo, Chulman, Cui, Mei, Tieu, Kim, Johnson, Gail V. W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585875/ https://www.ncbi.nlm.nih.gov/pubmed/23469253 http://dx.doi.org/10.1371/journal.pone.0057932 |
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