Pharmacokinetic Drug Interactions with Vandetanib during Coadministration with Rifampicin or Itraconazole

Objective: The aim of this study was to investigate the effects of a potent CYP3A4 inducer, rifampicin (Study A), and a potent CYP3A4 inhibitor, itraconazole (Study B), on the pharmacokinetics of a single 300mg dose of vandetanib in healthy subjects. Study Design and Setting: Two phase I, randomized...

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Detalles Bibliográficos
Autores principales: Martin, Paul, Oliver, Stuart, Robertson, Jane, Kennedy, Sarah-Jane, Read, Jessica, Duvauchelle, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2012
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586143/
https://www.ncbi.nlm.nih.gov/pubmed/21410294
http://dx.doi.org/10.2165/11586980-000000000-00000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586143/
https://www.ncbi.nlm.nih.gov/pubmed/21410294
http://dx.doi.org/10.2165/11586980-000000000-00000

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