Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum

The Plasmodium falciparum histone deacetylase Sir2a localizes at telomeric regions where it contributes to epigenetic silencing of clonally variant virulence genes. Apart from telomeres, PfSir2a also accumulates in the nucleolus, which harbours the developmentally regulated ribosomal RNA genes. Here...

Descripción completa

Detalles Bibliográficos
Autores principales: Mancio-Silva, Liliana, Lopez-Rubio, Jose Juan, Claes, Aurélie, Scherf, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586713/
https://www.ncbi.nlm.nih.gov/pubmed/23443558
http://dx.doi.org/10.1038/ncomms2539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586713/
https://www.ncbi.nlm.nih.gov/pubmed/23443558
http://dx.doi.org/10.1038/ncomms2539

Ejemplares similares