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Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity

Effective clinical application of antiviral immunotherapies necessitates enhancing the functional state of natural killer (NK) and CD8(+) T cells. An important mechanism for the establishment of viral persistence in the liver is the activation of the PD-1/PD-L1 inhibitory pathway. To examine the rol...

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Detalles Bibliográficos
Autores principales: Dolina, Joseph S, Sung, Sun-Sang J, Novobrantseva, Tatiana I, Nguyen, Tuyen M, Hahn, Young S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586800/
https://www.ncbi.nlm.nih.gov/pubmed/23423360
http://dx.doi.org/10.1038/mtna.2012.63