Cargando…

Structural Characterization of a Recombinant Fusion Protein by Instrumental Analysis and Molecular Modeling

Conbercept is a genetically engineered homodimeric protein for the treatment of wet age-related macular degeneration (wet AMD) that functions by blocking VEGF-family proteins. Its huge, highly variable architecture makes characterization and development of a functional assay difficult. In this study...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Zhigang, Zhou, Peng, Li, Xiaoxin, Wang, Hui, Luo, Delun, Qiao, Huaiyao, Ke, Xiao, Huang, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587646/ https://www.ncbi.nlm.nih.gov/pubmed/23469213 http://dx.doi.org/10.1371/journal.pone.0057642

Ejemplares similares

Novel VEGF Decoy Receptor Fusion Protein Conbercept Targeting Multiple VEGF Isoforms Provide Remarkable Anti-Angiogenesis Effect In Vivo
por: Wang, Qin, et al.
Publicado: (2013)

The Structural Characterization of Tumor Fusion Genes and Proteins
por: Wang, Dandan, et al.
Publicado: (2015)

Expression and Characterization of Recombinant S2 Subunit of SARS-coronavirus S Fusion Protein
por: Yan, Zhe, et al.
Publicado: (2009)

Biochemical and functional characterization of a recombinant monomeric factor VIII–Fc fusion protein
por: PETERS, R T, et al.
Publicado: (2013)

Enhanced Expression and Functional Characterization of the Recombinant Putative Lysozyme-PMAP36 Fusion Protein
por: Rao, Zhili, et al.
Publicado: (2019)

The recombinant expression and activity detection of MAF-1 fusion protein
por: Fu, Ping, et al.
Publicado: (2015)

Blockade of complement activation in bullous pemphigoid by using recombinant CD55-CD46 fusion protein
por: Qiao, Pei, et al.
Publicado: (2021)

Studies to Prevent Degradation of Recombinant Fc-Fusion Protein Expressed in Mammalian Cell Line and Protein Characterization
por: Chakrabarti, Sanjukta, et al.
Publicado: (2016)

Fusion with heat-resistant obscure (Hero) proteins have the potential to improve the molecular property of recombinant proteins
por: Morimoto, Eri, et al.
Publicado: (2022)

Comparison of Silicate-Substituted Calcium Phosphate (Actifuse) with Recombinant Human Bone Morphogenetic Protein-2 (Infuse) in Posterolateral Instrumented Lumbar Fusion
por: Licina, Paul, et al.
Publicado: (2015)

Chromophore attachment to fusion protein of streptavidin and recombinant allophycocyanin α subunit
por: Wu, Jing, et al.
Publicado: (2017)

Structural characterization of Mumps virus fusion protein core
por: Liu, Yueyong, et al.
Publicado: (2006)

Observation of total VEGF level in hyperglycemic mouse eyes after intravitreal injection of the novel anti-VEGF drug conbercept
por: Du, Liping, et al.
Publicado: (2015)

Design and Characterization of Novel Recombinant Listeriolysin O–Protamine Fusion Proteins for Enhanced Gene Delivery
por: Kim, Na Hyung, et al.
Publicado: (2014)

Posterior Instrumentation for Occipitocervical Fusion
por: Sapkas, George, et al.
Publicado: (2011)

One-stage posterior laminectomy with instrumented fusion and foraminotomy for cervical ossification of posterior longitudinal ligament with radiculopathy pain
por: Su, Bao, et al.
Publicado: (2021)

Structural characterization of the fusion core in syncytin, envelope protein of human endogenous retrovirus family W
por: Gong, Rui, et al.
Publicado: (2005)

Characterization of the fusion core in zebrafish endogenous retroviral envelope protein
por: Shi, Jian, et al.
Publicado: (2015)

Macromolecular and Solution Properties of the Recombinant Fusion Protein HUG
por: Sist, Paola, et al.
Publicado: (2022)

Structural Characterization of the SARS-Coronavirus Spike S Fusion Protein Core
por: Tripet, Brian, et al.
Publicado: (2004)

Structural Analysis of Recombinant Human Preproinsulins by Structure Prediction, Molecular Dynamics, and Protein-Protein Docking
por: Jung, Sung Hun, et al.
Publicado: (2017)

Structural and Functional Characterization of Recombinant Isoforms of the Lentil Lipid Transfer Protein
por: Bogdanov, I. V., et al.
Publicado: (2015)

Instrumented Posterolateral fusion versus instrumented Interbody fusion for degenerative lumbar diseases in uremic patients under hemodialysis
por: Ho, Chia-Ning, et al.
Publicado: (2020)

Molecular characterization, purification, and antioxidant activity of recombinant superoxide dismutase from the Pacific abalone Haliotis discus hannai Ino
por: Qiao, Kun, et al.
Publicado: (2020)

Expression, purification and characterization of a recombinant fusion protein based on the human papillomavirus-16 E7 antigen
por: Granadillo, Milaid, et al.
Publicado: (2013)

Human αB-crystallin as fusion protein and molecular chaperone increases the expression and folding efficiency of recombinant insulin
por: Akbarian, Mohsen, et al.
Publicado: (2018)

Rift Valley fever virus structural proteins: expression, characterization and assembly of recombinant proteins
por: Liu, Li, et al.
Publicado: (2008)

Comparison and Analysis of Timbre Fusion for Chinese and Western Musical Instruments
por: Liu, Jingyu, et al.
Publicado: (2022)

Expression and Immunogenicity of Two Recombinant Fusion Proteins Comprising Foot-and-Mouth Disease Virus Structural Protein VP1 and DC-SIGN-Binding Glycoproteins
por: Liu, Xinsheng, et al.
Publicado: (2017)

Major epiplasmic proteins of ciliates are articulins: cloning, recombinant expression, and structural characterization
Publicado: (1995)

Biophysical characterization of recombinant proteins: A key to higher structural genomics success
por: Vedadi, Masoud, et al.
Publicado: (2010)

Comparison of structural occipital and iliac bone grafts for instrumented atlantoaxial fusions in pediatric patients: Radiologic research and clinical outcomes
por: Liang, Zhi-Hui, et al.
Publicado: (2023)

Preliminary experience in treating thoracic spinal tuberculosis via a posterior modified transfacet debridement, instrumentation, and interbody fusion
por: Huang, Yun-Peng, et al.
Publicado: (2018)

Infection Recurrence in Instrumented Spinal Fusion in Children
por: Moyano, Carlos A., et al.
Publicado: (2020)

Fusion Rates of Lateral Lumbar Interbody Fusion Using Recombinant Human Bone Morphogenetic Protein-2
por: Nourian, Ardalan A., et al.
Publicado: (2018)

A recombinant single chain antibody interleukin-2 fusion protein.
por: Savage, P., et al.
Publicado: (1993)

Pharmacokinetics and Pharmacodynamics of Recombinant Human EPO-Fc Fusion Protein In Vivo
por: Shi, Xunlong, et al.
Publicado: (2013)

Plant-produced recombinant Osteopontin-Fc fusion protein enhanced osteogenesis
por: Rattanapisit, Kaewta, et al.
Publicado: (2019)

Immunological, structural, and preliminary X-ray diffraction characterizations of the fusion core of the SARS-coronavirus spike protein()
por: Hsu, Chun-Hua, et al.
Publicado: (2004)

Fundamental Characterization of Antibody Fusion-Single-Chain TNF Recombinant Proteins Directed against Costimulatory TNF Receptors Expressed by T-Lymphocytes
por: Nagai, Hodaka, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hf0hvssd5ttuc8keihvt6g8pek