Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress

Parkinson’s disease (PD) is one of the most common age-related neurodegenerative diseases. This pathology causes a significant loss of dopaminergic neurons in the Substantia Nigra. Several reports have claimed a role of defective nuclear and mitochondrial DNA repair pathways in PD etiology, in parti...

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Autores principales: Ciccone, Sarah, Maiani, Emiliano, Bellusci, Giovanna, Diederich, Marc, Gonfloni, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587993/
https://www.ncbi.nlm.nih.gov/pubmed/23348931
http://dx.doi.org/10.3390/ijms14022388
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author Ciccone, Sarah
Maiani, Emiliano
Bellusci, Giovanna
Diederich, Marc
Gonfloni, Stefania
author_facet Ciccone, Sarah
Maiani, Emiliano
Bellusci, Giovanna
Diederich, Marc
Gonfloni, Stefania
author_sort Ciccone, Sarah
collection PubMed
description Parkinson’s disease (PD) is one of the most common age-related neurodegenerative diseases. This pathology causes a significant loss of dopaminergic neurons in the Substantia Nigra. Several reports have claimed a role of defective nuclear and mitochondrial DNA repair pathways in PD etiology, in particular, of the Base Excision Repair (BER) system. In addition, recent findings, related to PD progression, indicate that oxidative stress pathways involving c-Abl and GST could also be implicated in this pathology. This review focuses on recently described networks most likely involved in an integrated manner in the course of PD.
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spelling pubmed-35879932013-03-13 Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress Ciccone, Sarah Maiani, Emiliano Bellusci, Giovanna Diederich, Marc Gonfloni, Stefania Int J Mol Sci Review Parkinson’s disease (PD) is one of the most common age-related neurodegenerative diseases. This pathology causes a significant loss of dopaminergic neurons in the Substantia Nigra. Several reports have claimed a role of defective nuclear and mitochondrial DNA repair pathways in PD etiology, in particular, of the Base Excision Repair (BER) system. In addition, recent findings, related to PD progression, indicate that oxidative stress pathways involving c-Abl and GST could also be implicated in this pathology. This review focuses on recently described networks most likely involved in an integrated manner in the course of PD. MDPI 2013-01-24 /pmc/articles/PMC3587993/ /pubmed/23348931 http://dx.doi.org/10.3390/ijms14022388 Text en © 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Ciccone, Sarah
Maiani, Emiliano
Bellusci, Giovanna
Diederich, Marc
Gonfloni, Stefania
Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress
title Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress
title_full Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress
title_fullStr Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress
title_full_unstemmed Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress
title_short Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress
title_sort parkinson’s disease: a complex interplay of mitochondrial dna alterations and oxidative stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587993/
https://www.ncbi.nlm.nih.gov/pubmed/23348931
http://dx.doi.org/10.3390/ijms14022388
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