Partial Peptide of α-Synuclein Modified with Small-Molecule Inhibitors Specifically Inhibits Amyloid Fibrillation of α-Synuclein

We have previously reported that pyrroloquinoline quinone (PQQ) prevents the amyloid formation of α-synuclein, amyloid β(1–42) (Aβ(1–42)), and mouse prion protein. Moreover, PQQ-modified α-synuclein and a proteolytic fragment of the PQQ-modified α-synuclein are able to inhibit the amyloid formation...

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Detalles Bibliográficos
Autores principales: Yoshida, Wataru, Kobayashi, Natsuki, Sasaki, Yasuhiko, Ikebukuro, Kazunori, Sode, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588004/
https://www.ncbi.nlm.nih.gov/pubmed/23358249
http://dx.doi.org/10.3390/ijms14022590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588004/
https://www.ncbi.nlm.nih.gov/pubmed/23358249
http://dx.doi.org/10.3390/ijms14022590

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