Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease
Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs functionally respond to DNA damage and describe several modifications in mESC DNA damage response, which accommodate dynamic cycling and preser...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588006/ https://www.ncbi.nlm.nih.gov/pubmed/23358251 http://dx.doi.org/10.3390/ijms14022617 |
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author | Giachino, Claudia Orlando, Luca Turinetto, Valentina |
author_facet | Giachino, Claudia Orlando, Luca Turinetto, Valentina |
author_sort | Giachino, Claudia |
collection | PubMed |
description | Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs functionally respond to DNA damage and describe several modifications in mESC DNA damage response, which accommodate dynamic cycling and preservation of genetic information. Subsequently, we will discuss how the transition from mESCs to adult stem/progenitor cells can be involved in the decline of tissue integrity and function in the elderly. |
format | Online Article Text |
id | pubmed-3588006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-35880062013-03-13 Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease Giachino, Claudia Orlando, Luca Turinetto, Valentina Int J Mol Sci Review Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs functionally respond to DNA damage and describe several modifications in mESC DNA damage response, which accommodate dynamic cycling and preservation of genetic information. Subsequently, we will discuss how the transition from mESCs to adult stem/progenitor cells can be involved in the decline of tissue integrity and function in the elderly. MDPI 2013-01-28 /pmc/articles/PMC3588006/ /pubmed/23358251 http://dx.doi.org/10.3390/ijms14022617 Text en © 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Giachino, Claudia Orlando, Luca Turinetto, Valentina Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease |
title | Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease |
title_full | Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease |
title_fullStr | Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease |
title_full_unstemmed | Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease |
title_short | Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease |
title_sort | maintenance of genomic stability in mouse embryonic stem cells: relevance in aging and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588006/ https://www.ncbi.nlm.nih.gov/pubmed/23358251 http://dx.doi.org/10.3390/ijms14022617 |
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