Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease

Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs functionally respond to DNA damage and describe several modifications in mESC DNA damage response, which accommodate dynamic cycling and preser...

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Detalles Bibliográficos
Autores principales: Giachino, Claudia, Orlando, Luca, Turinetto, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588006/
https://www.ncbi.nlm.nih.gov/pubmed/23358251
http://dx.doi.org/10.3390/ijms14022617
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author Giachino, Claudia
Orlando, Luca
Turinetto, Valentina
author_facet Giachino, Claudia
Orlando, Luca
Turinetto, Valentina
author_sort Giachino, Claudia
collection PubMed
description Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs functionally respond to DNA damage and describe several modifications in mESC DNA damage response, which accommodate dynamic cycling and preservation of genetic information. Subsequently, we will discuss how the transition from mESCs to adult stem/progenitor cells can be involved in the decline of tissue integrity and function in the elderly.
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spelling pubmed-35880062013-03-13 Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease Giachino, Claudia Orlando, Luca Turinetto, Valentina Int J Mol Sci Review Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs functionally respond to DNA damage and describe several modifications in mESC DNA damage response, which accommodate dynamic cycling and preservation of genetic information. Subsequently, we will discuss how the transition from mESCs to adult stem/progenitor cells can be involved in the decline of tissue integrity and function in the elderly. MDPI 2013-01-28 /pmc/articles/PMC3588006/ /pubmed/23358251 http://dx.doi.org/10.3390/ijms14022617 Text en © 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Giachino, Claudia
Orlando, Luca
Turinetto, Valentina
Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease
title Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease
title_full Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease
title_fullStr Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease
title_full_unstemmed Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease
title_short Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease
title_sort maintenance of genomic stability in mouse embryonic stem cells: relevance in aging and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588006/
https://www.ncbi.nlm.nih.gov/pubmed/23358251
http://dx.doi.org/10.3390/ijms14022617
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