Effect of Human Flavin-Containing Monooxygenase 3 Polymorphism on the Metabolism of Aurora Kinase Inhibitors

Aurora kinases were recently identified as a potential target in anticancer therapy and, amongst their available inhibitors, Tozasertib (VX-680) and Danusertib (PHA-739358) have been indicated as possible substrates of human flavin-containing monooxygenase 3 (hFMO3). Here we report the in vitro rate...

Descripción completa

Detalles Bibliográficos
Autores principales: Catucci, Gianluca, Occhipinti, Andrea, Maffei, Massimo, Gilardi, Gianfranco, Sadeghi, Sheila J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588010/
https://www.ncbi.nlm.nih.gov/pubmed/23358255
http://dx.doi.org/10.3390/ijms14022707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588010/
https://www.ncbi.nlm.nih.gov/pubmed/23358255
http://dx.doi.org/10.3390/ijms14022707

Ejemplares similares