Inhibition of Poly(ADP-Ribose) Polymerase Enhances Radiochemosensitivity in Cancers Proficient in DNA Double-Strand Break Repair

Pharmacologic inhibitors of poly(ADP-ribose) polymerase (PARP) putatively enhance radiation toxicity in cancer cells. Although there is considerable information on the molecular interactions of PARP and BRCA1- and BRCA2-deficient cancers, very little is known of the PARP inhibition effect upon cance...

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Detalles Bibliográficos
Autores principales: Shunkwiler, Lauren, Ferris, Gina, Kunos, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588069/
https://www.ncbi.nlm.nih.gov/pubmed/23396107
http://dx.doi.org/10.3390/ijms14023773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588069/
https://www.ncbi.nlm.nih.gov/pubmed/23396107
http://dx.doi.org/10.3390/ijms14023773

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