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A Human Genome-wide Screen for Regulators of Clathrin-coated Vesicle Formation Reveals an Unexpected Role for the V-ATPase

Clathrin-mediated endocytosis is essential for a wide range of cellular functions. We used a multi-step siRNA-based screening strategy to identify regulators of the first step in clathrin-mediated endocytosis, formation of clathrin-coated vesicles (CCVs) at the plasma membrane. A primary genome-wide...

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Detalles Bibliográficos
Autores principales: Kozik, Patrycja, Hodson, Nicola A., Sahlender, Daniela A., Simecek, Nikol, Soromani, Christina, Wu, Jiahua, Collinson, Lucy M., Robinson, Margaret S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588604/
https://www.ncbi.nlm.nih.gov/pubmed/23263279
http://dx.doi.org/10.1038/ncb2652