FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage

DNA damage as a result of environmental stress is recognized by sensor proteins that trigger repair mechanisms, or, if repair is unsuccessful, initiate apoptosis. Defects in DNA damage-induced apoptosis promote genomic instability and tumorigenesis. The protein ataxia-telangiectasia mutated (ATM) is...

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Detalles Bibliográficos
Autores principales: Chung, Young Min, Park, See-Hyoung, Tsai, Wen-Bin, Wang, Shih-Ya, Ikeda, Masa-Aki, Berek, Jonathan S., Chen, David J., Hu, Mickey C-T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589124/
https://www.ncbi.nlm.nih.gov/pubmed/22893124
http://dx.doi.org/10.1038/ncomms2008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589124/
https://www.ncbi.nlm.nih.gov/pubmed/22893124
http://dx.doi.org/10.1038/ncomms2008

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