Epigenetic Hierarchy within the MAGEA1 Cancer-Germline Gene: Promoter DNA Methylation Dictates Local Histone Modifications

Gene MAGEA1 belongs to a group of human germline-specific genes that rely on DNA methylation for repression in somatic tissues. Many of these genes, termed cancer-germline (CG) genes, become demethylated and activated in a wide variety of tumors, where they encode tumor-specific antigens. The proces...

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Detalles Bibliográficos
Autores principales: Cannuyer, Julie, Loriot, Axelle, Parvizi, Grégory K., De Smet, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589373/
https://www.ncbi.nlm.nih.gov/pubmed/23472218
http://dx.doi.org/10.1371/journal.pone.0058743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589373/
https://www.ncbi.nlm.nih.gov/pubmed/23472218
http://dx.doi.org/10.1371/journal.pone.0058743

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