Intersubunit Ionic Interactions Stabilize the Nucleoside Diphosphate Kinase of Mycobacterium tuberculosis

Most nucleoside diphosphate kinases (NDPKs) are hexamers. The C-terminal tail interacting with the neighboring subunits is crucial for hexamer stability. In the NDPK from Mycobacterium tuberculosis (Mt) this tail is missing. The quaternary structure of Mt-NDPK is essential for full enzymatic activit...

Descripción completa

Detalles Bibliográficos
Autores principales: Georgescauld, Florian, Moynié, Lucile, Habersetzer, Johann, Cervoni, Laura, Mocan, Iulia, Borza, Tudor, Harris, Pernile, Dautant, Alain, Lascu, Ioan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589492/
https://www.ncbi.nlm.nih.gov/pubmed/23526954
http://dx.doi.org/10.1371/journal.pone.0057867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589492/
https://www.ncbi.nlm.nih.gov/pubmed/23526954
http://dx.doi.org/10.1371/journal.pone.0057867

Ejemplares similares