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Intersubunit Ionic Interactions Stabilize the Nucleoside Diphosphate Kinase of Mycobacterium tuberculosis

Most nucleoside diphosphate kinases (NDPKs) are hexamers. The C-terminal tail interacting with the neighboring subunits is crucial for hexamer stability. In the NDPK from Mycobacterium tuberculosis (Mt) this tail is missing. The quaternary structure of Mt-NDPK is essential for full enzymatic activit...

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Detalles Bibliográficos
Autores principales:	Georgescauld, Florian, Moynié, Lucile, Habersetzer, Johann, Cervoni, Laura, Mocan, Iulia, Borza, Tudor, Harris, Pernile, Dautant, Alain, Lascu, Ioan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589492/ https://www.ncbi.nlm.nih.gov/pubmed/23526954 http://dx.doi.org/10.1371/journal.pone.0057867

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