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Obligate Ligation-Gated Recombination (ObLiGaRe): Custom-designed nuclease-mediated targeted integration through nonhomologous end joining

Custom-designed nucleases (CDNs) greatly facilitate genetic engineering by generating a targeted DNA double-strand break (DSB) in the genome. Once a DSB is created, specific modifications can be introduced around the breakage site during its repair by two major DNA damage repair (DDR) mechanisms: th...

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Detalles Bibliográficos
Autores principales:	Maresca, Marcello, Lin, Victor Guosheng, Guo, Ning, Yang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2013
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589542/ https://www.ncbi.nlm.nih.gov/pubmed/23152450 http://dx.doi.org/10.1101/gr.145441.112

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