A Segment of 97 Amino Acids within the Translocation Domain of Clostridium difficile Toxin B Is Essential for Toxicity

Clostridium difficile toxin B (TcdB) intoxicates target cells by glucosylating Rho GTPases. TcdB (269 kDa) consists of at least 4 functional domains including a glucosyltransferase domain (GTD), a cysteine protease domain (CPD), a translocation domain (TD), and a receptor binding domain (RBD). The f...

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Detalles Bibliográficos
Autores principales: Zhang, Yongrong, Shi, Lianfa, Li, Shan, Yang, Zhiyong, Standley, Clive, Yang, Zhong, ZhuGe, Ronghua, Savidge, Tor, Wang, Xiaoning, Feng, Hanping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590123/
https://www.ncbi.nlm.nih.gov/pubmed/23484044
http://dx.doi.org/10.1371/journal.pone.0058634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590123/
https://www.ncbi.nlm.nih.gov/pubmed/23484044
http://dx.doi.org/10.1371/journal.pone.0058634

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