Cargando…

A Segment of 97 Amino Acids within the Translocation Domain of Clostridium difficile Toxin B Is Essential for Toxicity

Clostridium difficile toxin B (TcdB) intoxicates target cells by glucosylating Rho GTPases. TcdB (269 kDa) consists of at least 4 functional domains including a glucosyltransferase domain (GTD), a cysteine protease domain (CPD), a translocation domain (TD), and a receptor binding domain (RBD). The f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yongrong, Shi, Lianfa, Li, Shan, Yang, Zhiyong, Standley, Clive, Yang, Zhong, ZhuGe, Ronghua, Savidge, Tor, Wang, Xiaoning, Feng, Hanping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590123/ https://www.ncbi.nlm.nih.gov/pubmed/23484044 http://dx.doi.org/10.1371/journal.pone.0058634

Ejemplares similares

The Enterotoxicity of Clostridium difficile Toxins
por: Sun, Xingmin, et al.
Publicado: (2010)

Cysteine Protease-Mediated Autocleavage of Clostridium difficile Toxins Regulates Their Proinflammatory Activity
por: Zhang, Yongrong, et al.
Publicado: (2018)

Identification of Toxemia in Patients with Clostridium difficile Infection
por: Yu, Hua, et al.
Publicado: (2015)

Utility of Clostridium difficile Toxin B for Inducing Anti-Tumor Immunity
por: Huang, Tuxiong, et al.
Publicado: (2014)

Identification of an Essential Region for Translocation of Clostridium difficile Toxin B
por: Chen, Shuyi, et al.
Publicado: (2016)

Structure of the full-length Clostridium difficile toxin B
por: Chen, Peng, et al.
Publicado: (2019)

Correction: Chen, S., et al. Identification of an Essential Region for Translocation of Clostridium difficile Toxin B. Toxins 2016, 8, 241
por: Chen, Shuyi, et al.
Publicado: (2016)

Retargeting Clostridium difficile Toxin B to Neuronal Cells as a Potential Vehicle for Cytosolic Delivery of Therapeutic Biomolecules to Treat Botulism
por: Krautz-Peterson, Greice, et al.
Publicado: (2012)

Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium
por: Yang, Guilin, et al.
Publicado: (2008)

A fine-tuned yeast surface-display/secretion platform enables the rapid discovery of neutralizing antibodies against Clostridioides difficile toxins
por: Sun, Ying, et al.
Publicado: (2023)

Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B
por: Yuan, Pengfei, et al.
Publicado: (2015)

Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B
por: Genth, Harald, et al.
Publicado: (2016)

Toxin B is essential for virulence of Clostridium difficile
por: Lyras, Dena, et al.
Publicado: (2009)

The Association between GABA-Modulators and Clostridium difficile Infection – A Matched Retrospective Case-Control Study
por: Ström, Jonathan, et al.
Publicado: (2017)

Binary Toxin and Death after Clostridium difficile Infection
por: Bacci, Sabrina, et al.
Publicado: (2011)

Spore Formation and Toxin Production in Clostridium difficile Biofilms
por: Semenyuk, Ekaterina G., et al.
Publicado: (2014)

The Role of Rho GTPases in Toxicity of Clostridium difficile Toxins
por: Chen, Shuyi, et al.
Publicado: (2015)

The Regulatory Networks That Control Clostridium difficile Toxin Synthesis
por: Martin-Verstraete, Isabelle, et al.
Publicado: (2016)

EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin
por: Schnell, Leonie, et al.
Publicado: (2016)

Clostridium difficile Infection Caused by Binary Toxin–Positive Strains
por: Hensgens, Marjolein P.M., et al.
Publicado: (2013)

Genes Encoding Toxin of Clostridium difficile in Children with and without Diarrhea
por: Merino, Victor R. C., et al.
Publicado: (2014)

Toxin Synthesis by Clostridium difficile Is Regulated through Quorum Signaling
por: Darkoh, Charles, et al.
Publicado: (2015)

Increased toxin expression in a Clostridium difficile mfd mutant
por: Willing, Stephanie E., et al.
Publicado: (2015)

Frizzled are colonic epithelial receptors for Clostridium difficile toxin B
por: Tao, Liang, et al.
Publicado: (2016)

Whole genome sequences of three Clade 3 Clostridium difficile strains carrying binary toxin genes in China
por: Chen, Rong, et al.
Publicado: (2017)

The development of live biotherapeutics against Clostridioides difficile infection towards reconstituting gut microbiota
por: Zhang, Yongrong, et al.
Publicado: (2022)

Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
por: Kuehne, Sarah A., et al.
Publicado: (2014)

Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B
por: Simeon, Rudo, et al.
Publicado: (2019)

Time-resolved amino acid uptake of Clostridium difficile 630Δerm and concomitant fermentation product and toxin formation
por: Neumann-Schaal, Meina, et al.
Publicado: (2015)

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins
por: Shen, Aimee, et al.
Publicado: (2011)

Toward a structural understanding of Clostridium difficile toxins A and B
por: Pruitt, Rory N., et al.
Publicado: (2012)

Proteomic Analysis and Label-Free Quantification of the Large Clostridium difficile Toxins
por: Moura, Hercules, et al.
Publicado: (2013)

Bile Salt Inhibition of Host Cell Damage by Clostridium Difficile Toxins
por: Darkoh, Charles, et al.
Publicado: (2013)

Effects of Clostridium difficile Toxin A and B on Human T Lymphocyte Migration
por: Wu, Dan, et al.
Publicado: (2013)

Clostridium difficile toxin B induces autophagic cell death in colonocytes
por: Chan, Hung, et al.
Publicado: (2018)

Lectin Activity of the TcdA and TcdB Toxins of Clostridium difficile
por: Hartley-Tassell, Lauren E., et al.
Publicado: (2019)

Effect of natural products on the production and activity of Clostridium difficile toxins in vitro
por: Roshan, Niloufar, et al.
Publicado: (2018)

Toxin release mediated by the novel autolysin Cwp19 in Clostridium difficile
por: El Meouche, Imane, et al.
Publicado: (2018)

A genetic switch controls the production of flagella and toxins in Clostridium difficile
por: Anjuwon-Foster, Brandon R., et al.
Publicado: (2017)

Correction: Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B
por: Simeon, Rudo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_89u441b053jsee5q7db8svcg2u