Prediction of Depression in Individuals at High Familial Risk of Mood Disorders Using Functional Magnetic Resonance Imaging

OBJECTIVE: Bipolar disorder is a highly heritable condition. First-degree relatives of affected individuals have a more than a ten-fold increased risk of developing bipolar disorder (BD), and a three-fold risk of developing major depressive disorder (MDD) than the general population. It is unclear h...

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Autores principales: Whalley, Heather C., Sussmann, Jessika E., Romaniuk, Liana, Stewart, Tiffany, Papmeyer, Martina, Sprooten, Emma, Hackett, Suzanna, Hall, Jeremy, Lawrie, Stephen M., McIntosh, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590244/
https://www.ncbi.nlm.nih.gov/pubmed/23483904
http://dx.doi.org/10.1371/journal.pone.0057357
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author Whalley, Heather C.
Sussmann, Jessika E.
Romaniuk, Liana
Stewart, Tiffany
Papmeyer, Martina
Sprooten, Emma
Hackett, Suzanna
Hall, Jeremy
Lawrie, Stephen M.
McIntosh, Andrew M.
author_facet Whalley, Heather C.
Sussmann, Jessika E.
Romaniuk, Liana
Stewart, Tiffany
Papmeyer, Martina
Sprooten, Emma
Hackett, Suzanna
Hall, Jeremy
Lawrie, Stephen M.
McIntosh, Andrew M.
author_sort Whalley, Heather C.
collection PubMed
description OBJECTIVE: Bipolar disorder is a highly heritable condition. First-degree relatives of affected individuals have a more than a ten-fold increased risk of developing bipolar disorder (BD), and a three-fold risk of developing major depressive disorder (MDD) than the general population. It is unclear however whether differences in brain activation reported in BD and MDD are present before the onset of illness. METHODS: We studied 98 young unaffected individuals at high familial risk of BD and 58 healthy controls using functional Magnetic Resonance Imaging (fMRI) scans and a task involving executive and language processing. Twenty of the high-risk subjects subsequently developed MDD after the baseline fMRI scan. RESULTS: At baseline the high-risk subjects who later developed MDD demonstrated relatively increased activation in the insula cortex, compared to controls and high risk subjects who remained well. In the healthy controls and high-risk group who remained well, this region demonstrated reduced engagement with increasing task difficulty. The high risk subjects who subsequently developed MDD did not demonstrate this normal disengagement. Activation in this region correlated positively with measures of cyclothymia and neuroticism at baseline, but not with measures of depression. CONCLUSIONS: These results suggest that increased activation of the insula can differentiate individuals at high-risk of bipolar disorder who later develop MDD from healthy controls and those at familial risk who remain well. These findings offer the potential of future risk stratification in individuals at risk of mood disorder for familial reasons.
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spelling pubmed-35902442013-03-12 Prediction of Depression in Individuals at High Familial Risk of Mood Disorders Using Functional Magnetic Resonance Imaging Whalley, Heather C. Sussmann, Jessika E. Romaniuk, Liana Stewart, Tiffany Papmeyer, Martina Sprooten, Emma Hackett, Suzanna Hall, Jeremy Lawrie, Stephen M. McIntosh, Andrew M. PLoS One Research Article OBJECTIVE: Bipolar disorder is a highly heritable condition. First-degree relatives of affected individuals have a more than a ten-fold increased risk of developing bipolar disorder (BD), and a three-fold risk of developing major depressive disorder (MDD) than the general population. It is unclear however whether differences in brain activation reported in BD and MDD are present before the onset of illness. METHODS: We studied 98 young unaffected individuals at high familial risk of BD and 58 healthy controls using functional Magnetic Resonance Imaging (fMRI) scans and a task involving executive and language processing. Twenty of the high-risk subjects subsequently developed MDD after the baseline fMRI scan. RESULTS: At baseline the high-risk subjects who later developed MDD demonstrated relatively increased activation in the insula cortex, compared to controls and high risk subjects who remained well. In the healthy controls and high-risk group who remained well, this region demonstrated reduced engagement with increasing task difficulty. The high risk subjects who subsequently developed MDD did not demonstrate this normal disengagement. Activation in this region correlated positively with measures of cyclothymia and neuroticism at baseline, but not with measures of depression. CONCLUSIONS: These results suggest that increased activation of the insula can differentiate individuals at high-risk of bipolar disorder who later develop MDD from healthy controls and those at familial risk who remain well. These findings offer the potential of future risk stratification in individuals at risk of mood disorder for familial reasons. Public Library of Science 2013-03-06 /pmc/articles/PMC3590244/ /pubmed/23483904 http://dx.doi.org/10.1371/journal.pone.0057357 Text en © 2013 Whalley et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Whalley, Heather C.
Sussmann, Jessika E.
Romaniuk, Liana
Stewart, Tiffany
Papmeyer, Martina
Sprooten, Emma
Hackett, Suzanna
Hall, Jeremy
Lawrie, Stephen M.
McIntosh, Andrew M.
Prediction of Depression in Individuals at High Familial Risk of Mood Disorders Using Functional Magnetic Resonance Imaging
title Prediction of Depression in Individuals at High Familial Risk of Mood Disorders Using Functional Magnetic Resonance Imaging
title_full Prediction of Depression in Individuals at High Familial Risk of Mood Disorders Using Functional Magnetic Resonance Imaging
title_fullStr Prediction of Depression in Individuals at High Familial Risk of Mood Disorders Using Functional Magnetic Resonance Imaging
title_full_unstemmed Prediction of Depression in Individuals at High Familial Risk of Mood Disorders Using Functional Magnetic Resonance Imaging
title_short Prediction of Depression in Individuals at High Familial Risk of Mood Disorders Using Functional Magnetic Resonance Imaging
title_sort prediction of depression in individuals at high familial risk of mood disorders using functional magnetic resonance imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590244/
https://www.ncbi.nlm.nih.gov/pubmed/23483904
http://dx.doi.org/10.1371/journal.pone.0057357
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