Aprotinin May Increase Mortality in Low and Intermediate Risk but Not in High Risk Cardiac Surgical Patients Compared to Tranexamic Acid and ε-Aminocaproic Acid – A Meta-Analysis of Randomised and Observational Trials of over 30.000 Patients

BACKGROUND: To compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of cardiac surgery. METHODS AND FINDINGS: We performed a meta-analysis of randomised control...

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Detalles Bibliográficos
Autores principales: Meybohm, Patrick, Herrmann, Eva, Nierhoff, Julia, Zacharowski, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590293/
https://www.ncbi.nlm.nih.gov/pubmed/23483965
http://dx.doi.org/10.1371/journal.pone.0058009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590293/
https://www.ncbi.nlm.nih.gov/pubmed/23483965
http://dx.doi.org/10.1371/journal.pone.0058009

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