Optimized siRNA-PEG Conjugates for Extended Blood Circulation and Reduced Urine Excretion in Mice

Some of the main concerns with in vivo application of naked small interfering RNA are rapid degradation and urinary excretion resulting in a short plasma half-life. In this study we investigated how conjugation of polyethylene glycol (PEG) with variable chain length affects siRNA pharmacokinetics an...

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Detalles Bibliográficos
Autores principales: Iversen, Frank, Yang, Chuanxu, Dagnæs-Hansen, Frederik, Schaffert, David H., Kjems, Jørgen, Gao, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590589/
https://www.ncbi.nlm.nih.gov/pubmed/23471415
http://dx.doi.org/10.7150/thno.5743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590589/
https://www.ncbi.nlm.nih.gov/pubmed/23471415
http://dx.doi.org/10.7150/thno.5743

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